Transporting patients to the hospitals in emergencies, the heliport is usually located on the roof of the hospital. This may cause the exhaust emitting from the helicopter to get into the air-intakes of the ventilation equipment on the roof, open entrances, and windows, leading to odor complaints and health related issues inside the hospital. Considering complexity of the problem and number of the design parameters, this study used CFD to investigate the helicopter exhaust fume entrainments into the hospital under different wind directions and speed, which helps find the optimum placement for air-intakes to reduce the particles and gas entrainment.