Presented are two R404A replacements: R448A (non-flammable; GWP = 1273) and R455A (mildly flammable; GWP = 146). A commercially available R404A self-contained freezer showed that the compressor run-times of R448A and R455A are similar to R404A due to similar capacity. The 24 hour energy consumption is 9% lower for R448A and 6% lower for R455A compared to R404A. Results for R448A in a commercially available walk-in freezer/cooler matched the capacity of R404A with 4% to 8% higher efficiency. Finally, results of an actual supermarket refrigeration system conversion from R404A to R448A showed energy savings from about 9% to 20%.