A premature baby is defined as the baby born in the 22th-37th week of the pregnancy. A baby, born before the 28th week of the pregnancy, can live inside of a newborn incubator with a thermoregulation system. Newborn’s death occurs by water and heat loss due to diseases. A decrement in body temperature causes hypothermia and an increment in body temperature causes hyperthermia that result by the death of the neonatal. For the survival of these babies, a suitable and controllable environment has to be provided. In this study, numerical and experimental analyses of a newborn incubator with a laminar flow unit are investigated.