UV-C technology has been used as a disinfection method for decades in the healthcare industry. The UV-C wavelength of 253.7 nanometers has been proven to be effective at eliminating or neutralizing dangerous pathogens like C. difficile, Methicillin resistant Staphylococcus aureus and more. The current technologies focus on cleaning surfaces to reduce healthcare associated infections. Three studies were conducted at an acute care hospital, a children’s hospital and a long term acute care facility to determine if reducing the number of colony forming units of bacteria and/or fungus in the air would improve indoor air quality.