Liquid desiccant heat exchangers (LDHX) can improve the performance of many HVAC systems by replacing traditional finned-tube coils. Adding LDHX technology to a vapor compression system effectively raises the evaporator temperature, while still delivering dry air. It also enables separate control of sensible and latent cooling, ensuring occupant comfort in humid climates. This presentation will discuss (1) background on an innovative LDHX design, including a comparison to other liquid desiccant options, (2) modeling and laboratory testing of the LDHX modules, and (3) modeling of a 20-ton dedicated-outdoor air system using these LDHXs.