The residential building sector is responsible for about 26% of total energy consumption in the European Union and account for 75% of the total building stock. About 64% of the residential buildings were constructed before the 80s and the widespread adoption of energy efficiency regulations. In the framework of a European research project there is an ongoing multinational effort to develop a conceptual framework for monitoring the effectiveness of energy efficiency measures (EEMs) applied in European residential buildings. The conceptual framework is based on national residential building typologies for single- and multi-family houses. The goal is to derive suitable energy performance indicators that will enable stakeholders on different scales to ensure a high quality of energy refurbishment plans, check compliance with regulations, track and steer the refurbishment processes in a cost-effective way and quantify actual energy savings in order to meet regional or national targets. This paper will provide an overview of these efforts and focus on the results from the Hellenic pilot action within EPICOPE.