One of the most important relationships in the commissioning process is between the commissioning agent, the owner and the engineer of record (EOR). A relationship that requires ongoing coordination with common goals defined from the beginning of the project. But what happens during Design-Build projects when the relationship between the EOR and contractors may result in different goals and can cause a conflict of interest? This paper provides a resource for all commissioning agents participating in a design-build project and offers guidelines to use to navigate from design to construction and to occupancy as effectively as possible.