The total environmental impact of leading lower GWP replacement refrigerants for R410A and R134a based chillers must be considered. There are several alternate refrigerants with lower GWP’s than R410A and R134a, but the direct emissions are only one contributor to the total global warming impact. The impact on efficiency must also be considered. Chillers are very high efficiency and low leak products so the impact from direct emissions is low compared to indirect. Results on annualized analysis of the efficiency including the impact of refrigerant cycle performance changes and heat transfer changes across all 19 climate zones will be presented.