In the early design of new data centers or modification of existing ones, the need for an optimal solution of many design parameters such as inlet air flow rate, inlet temperature, and server heat load is of paramount importance. The traditional way using computational fluid dynamics (CFD) to create alternative designs options can be problematic because of their intensive running time. This presentation introduces the Response Surface Methodology (RSM), which is based on CFD data but allows the study of many design parameters in data centers more feasible and economical in terms of modeling time while preserving reasonable accuracy.