This presentation focuses on the application of low global warming potential (GWP) alternative fluids for commercial stand-alone applications. The presented non-flammable and mildly flammable molecules will cover HFO’s and HFO blends which provide lower or very low GWP (below 150). Experimental system test data as well as thermodynamic simulation and design characteristics are discussed compared to current solutions to underline the performance of these new fluid options.