This presentation provides fundamental design data that supports optimal diffuser selection in mixing ventilation with heating and cooling operation. It shows how diffuser adjustment, room-supply air temperature differences and return air grille location impact ADPI and EV. The study points out connections between ADPI and EV and shows similarities and differences for heating and cooling operation. It presents the operation characteristic that provide good EV while maintaining acceptable ADPI. Also, it shows how diffuser adjustment may improve EV. Furthermore, the presentation shows the cases where return air location may have a significant effect on ADPI and EV.