Laboratory exhaust systems are a central element of high performance science and technology facilities. Air quality, energy efficiency, and operational reliability are deeply impacted by the performance and design of the laboratory exhaust system. This presentation focuses on the design process, considerations, fan basics and control of high performance lab exhaust systems. Brief design application examples will be included to connect fundamentals with practice. The objectives of this presentation are to provide guidance on design team collaboration, insights on lab exhaust design fundamentals and share examples of application.