Thermal comfort quality impacts health care workers’ outcomes and patients’ well-being. However, unlike any other type of indoor environments there is often a great variability in activity levels and health condition among occupants in a health care space that makes it difficult to achieve acceptable conditions for certain groups of occupants without sacrificing other groups. This seminar examines types of wearable sensors, their requirements and mappings in assessing individual thermal comfort and how such individual comfort data can be used to drive the operation of personalized and room indoor climate systems in real-time.