Relative humidity has a significant impact on indoor buildings and occupants. Specifically relative humidity impacts occupant health and comfort, as well as building energy usage and preservation. The ASHRAE Handbooks reference humidity over 300 times. Recent changes to the building envelope, HVAC equipment, and occupant requirements will impact ASHRAE humidity recommendations. There are many different HVAC product solutions that can be applied based on ASHRAE’s guidance. This seminar highlights some of the significant interactions concerning humidity levels, as well as outlining significant humidity recommendations and gaps.