There is significant interest in the adoption of low global warming potential (GWP) refrigerants. However, the heat transfer performance of these refrigerants is not well documented. This paper investigates alternate R410A refrigerants such as R32 and R452B. Fewer than 10 papers have been located which report heat transfer and pressure drop data for R32 and no papers have been located which report heat transfer and pressure drop data for R452B. The predicted performance of low GWP R410A alternatives will be compared to baseline values for R410A and impact on evaporator and condenser design will be discussed.